2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine

A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.

Also Known As:

Lysyl Hydroxylase; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Collagen Lysyl Hydroxylase; 2-Oxoglutarate Dioxygenase, Lysine; 5-Dioxygenase Procollagen-Lysine, 2-Oxoglutarate; Dioxygenase, Lysine 2-Oxoglutarate; Hydroxylase, Collagen Lysyl; Hydroxylase, Lysine; Hydroxylase, Lysyl; Hydroxylase, Protocollagen Lysyl; Lysine 2 Oxoglutarate Dioxygenase; Procollagen Lysine, 2 Oxoglutarate 5 Dioxygenase; Lysine 2-Oxoglutarate Dioxygenase; Lysine Hydroxylase; Protocollagen Lysyl Hydroxylase; Procollagen- L- lysine,2- oxoglutarate:oxygen oxidoreductase (5-hydroxylating)

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine: 143

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Disease

Drug/Important Bio-Agent (IBA)